Primeadine® Original Spermidine

Primeadine® Original Spermidine is a premium, plant-derived longevity supplement designed to rejuvenate your cells from within. Each serving provides 1 mg of naturally occurring spermidine – a polyamine compound clinically shown to trigger autophagy, the body’s natural cellular renewal process that clears damaged proteins and supports healthy ageing.

Sourced from defatted Japanese wheat germ extract, this formula also provides prebiotic fibre (FOS) to nourish beneficial gut bacteria, enhancing your body’s ability to produce its own spermidine. Unlike synthetic versions, Primeadine® delivers spermidine in its purest food-derived form, ensuring exceptional bioavailability and tolerance.

This award-winning supplement supports key longevity pathways: from mitochondrial function (your cells’ energy engines) and cognitive performance to hormone balance, improved sleep, radiance in skin as well as hair growth (even reversal of grey hair). With consistent use, many users report improved focus, vitality, and resilience against everyday stress.

Think of Primeadine® as fasting in a capsule. It activates many of the same longevity pathways triggered by intermittent fasting, without calorie restriction. We love Primeadine® Original for its purity, sourcing, and integrity. Made with defatted Japanese wheat germ to remove inflammatory oils, it’s produced under the world’s highest food safety standards and rigorously tested for purity and potency. It’s one of the cleanest, most scientifically grounded spermidine supplements on the market – and a true essential for anyone investing in graceful, active ageing.

Oxford Healthspan was founded by Harvard-trained longevity expert Leslie Kenny, who successfully reversed multiple autoimmune conditions. Working with Oxford University scientists, she launched Primeadine® in 2020 to make research-backed longevity solutions accessible. Now 60 with a biological age of 21, she is on a mission to help others improve their healthspan.

At Blue Essentials, we hold every product to the highest standard – backed by science, proven safe, and cost-effective. This is the Blue Standard.

Take 3 capsules per day with water, ideally at your first or last meal. If you find 3 capsules too many to take at once, you can split the dose across the day.

Have you heard of "Hara Hachi Bu"? It's a Japanese phrase meaning "eat until you're 80 percent full". Originating from Okinawa, one of the world’s Blue Zones, this mindful habit helps prevent overeating, supports digestion and metabolism, and is linked to longevity and healthier ageing.

Each serving provides 1mg of supplemental plant-derived spermidine from concentrated, defatted Japanese wheat* germ extract. Defatting removes omega-6 fatty acids, reducing the risk of rancidity and inflammation. Defatted wheat germ is also more easily absorbed in the GI tract due to its high molecular mass.

Other ingredients: Prebiotic Fiber (FOS) from Resistant Dextrin (Beetroot), Hypromellose (Vegan Cellulose Capsule), Sodium Citrate.

*Allergens: Wheat (Contains 40mg of gluten). In comparison, the average slice of bread contains 1,000-2,000mg of gluten.